Bioelectrical regulation of cell cycle and the planarian model systemby Paul G. Barghouth, Manish Thiruvalluvan, Néstor J. Oviedo

Biochimica et Biophysica Acta (BBA) - Biomembranes

About

Year
2015
DOI
10.1016/j.bbamem.2015.02.024
Subject
Biochemistry / Biophysics / Cell Biology

Text

12Q1 3Q2 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28progression and cancer transformation. Furthermore, we present the planarian 29 30 31 32 334 35 6 3738 39 . . . . 40 ) . . . 41 . . . . 42 ation . 43 c flow . 44 . . . 45 ium dyn 46 47 48 4. TMP and cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0 49 50 51 52 53 54 55 . . . . . . . . . . 0 56 . . . . . . . . . . 0 57 . . . . . . . . . . 0 58

Biochimica et Biophysica Acta xxx (2015) xxx–xxx

BBAMEM-81830; No. of pages: 9; 4C: 3, 6

Contents lists available at ScienceDirect

Biochimica et Biophysica Acta j ourna l homepage: www.e lsev ie r .com/ locate /bbamemUConflict of interest . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .N

C4.1. Cancer progression . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 04.2. Escaping cell death . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0 4.3. Cancer cell migration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0 4.4. Abrogation of cancer growth . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0 5. S. mediterranea and TMP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0 6. Concluding remarks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0☆ This article is part of a Special Issue entitled: Membra ⁎ Corresponding author at: Department of Molecular a

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E-mail address: noviedo2@ucmerced.edu (N.J. Oviedo 1 Equal contribution. http://dx.doi.org/10.1016/j.bbamem.2015.02.024 0005-2736/© 2015 Elsevier B.V. All rights reserved.

Please cite this article as: P.G. Barghouth, et (2015), http://dx.doi.org/10.1016/j.bbamem. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0O3.2.3. Calcium dynamics . . . .3.3. Plasma membrane dynamics . . .Contents 1. Introduction . . . . . . . . . . 2. The transmembrane potential (TMP 3. TMP and cell cycle regulation . . 3.1. TMP and membrane polariz 3.2. Generation of TMP and ioni 3.2.1. Chloride dynamics 3.2.2. Sodium and potass R

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TEat both the cellular and organismal level. This article is part of a Special Issue entitled: Membrane channels andtransporters in cancers. © 2015 Elsevier B.V. All rights reserved. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0 amics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0Planarian Schmidtea mediterranea as a tractable model system for understanding principles behindmolecular bioelectricityCancer

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Bioelectrical regulation of cell cycle and the planarian model system☆

Paul G. Barghouth a,b,1, Manish Thiruvalluvan a,b,1, Néstor J. Oviedo a,b,c,⁎ a Department of Molecular and Cell Biology, School of Natural Sciences, University of California at Merced, 5200 North Lake Road, Merced, CA 95343, USA b Quantitative and Systems Biology Graduate Program, University of California at Merced, 5200 North Lake Road, Merced, CA 95343, USA c Health Sciences Research Institute, University of California at Merced, 5200 North Lake Road, Merced, CA 95343, USA a b s t r a c ta r t i c l e i n f o

Article history:

Received 13 October 2014

Received in revised form 13 February 2015

Accepted 23 February 2015

Available online xxxx

Keywords:

Membrane potential

Cell cycle regulation through themanipulation of endogenousmembrane potentials offers tremendous opportunities to control cellular processes during tissue repair and cancer formation. However, the molecular mechanisms by which biophysical signals modulate the cell cycle remain underappreciated and poorly understood.

Cells in complex organisms generate and maintain a constant voltage gradient across the plasma membrane known as the transmembrane potential. This potential, generated through the combined efforts of various ion transporters, pumps and channels, is known to drive a wide range of cellular processes such as cellular proliferation, migration and tissue regeneration while its deregulation can lead to tumorigenesis. These cellular regulatory events, coordinated by ionic flow, correspond to a new and exciting field termed molecular bioelectricity. cussion on the biophysical machinery involvingmembrane potential and themech-ne channels and transporters in cancers. nd Cell Biology, School of Natural Sciences, University of California at Merced, 5200 North Lake Road, Merced, CA 95343, USA. ). al., Bioelectrical regulation of cell cycle and the planarian model system, Biochim. Biophys. Acta .2015.02.024

T59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 2 P.G. Barghouth et al. / Biochimica et Biophysica Acta xxx (2015) xxx–xxxU